Record Display for the EPA National Library Catalog


Main Title Survival of the Fattest: Implications for Acute Effects of Lipophilic Chemicals on Aquatic Populations.
Author Lassiter, R. R. ; Hallam., T. G. ;
CORP Author Environmental Research Lab., Athens, GA. ;Tennessee Univ., Knoxville.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/153;
Stock Number PB91-109918
Additional Subjects Lipids ; Mathematical models ; Toxicology ; Exposure ; Bioassays ; Fats ; Fishes ; Reprints ; Toxic substances ; Water pollution effects(Animals) ; Aquatic ecosystems ; Biological effects ; Population dynamics ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB91-109918 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Simple assumptions for individual toxic response, exchange of toxicant with environmental concentrations and body composition are used in a model to evaluate the effect of lipid variation on toxic response in a subpopulation of similarly sized individuals. The model represents the internal distribution of a chemical such that more hydrophobic compounds preferentially move into body lipid. Thus, for exposures of equal chemical activity, both increasing body fat and greater hydrophobicities increase the exposure duration that can be withstood without effect. In simulated 96-h bioassays, the effect of increased tolerance to higher hydrophobicities was apparent for chemicals whose K(sub ow) exceeded 10,000. These simulations are compared to published observations. Simulations also are compared to other published data for longer-term bioassays. The effect of interspecies gill morphology on toxic response also is explored. It is concluded that variation in lipid can account for much variation in tolerance in a subpopulation of similarly sized individuals; that gill morphology is another variable influencing toxic response; and that, in general, for similarly exposed organisms, the fattest survives the longest.