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RECORD NUMBER: 1 OF 2

Main Title Elimination of Urinary Cotinine in Children Exposed to Known Levels of Side-Stream Cigarette Smoke.
Author Goldstein, G. M. ; Collier, A. ; Etzel, R. ; Lewtas, J. ; Haley, N. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Centers for Disease Control, Atlanta, GA. ;American Health Foundation, Inc., Valhalla, NY. Naylor Dana Inst. for Disease Prevention.
Year Published 1987
Report Number EPA/600/D-87/087;
Stock Number PB87-174801
Additional Subjects Smoke ; Tobacco ; Children ; Nicotine ; Exposure ; Toxicity ; Urine ; Cotinine ; Health risks ; Drug dose response relationship ; Side stream smoke ; Cigarette smoking
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB87-174801 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract
The establishment of a quantitative personal marker of side-stream smoke exposure in children is important in the study of potential health effects in the group. Cotinine, a metabolite of nicotine, has been shown to exhibit a dose-response relationship to side-stream smoke exposure in adults, and has been used to quantitate prior exposure. The study was undertaken to determine the dose of nicotine, the peak level of urinary cotinine, the time to peak cotinine levels, and the elimination half-life of cotinine in young children exposed to a controlled amount of side-stream smoke. With an exposure to 26.4 ug/cu m of nicotine, nine children averaging 2.03 years old had peak cotinine/creatinine levels of 818 ng/mg. The time to peak cotinine was 4.1 hours, with an elimination half-life of 3.6 hours.