||Dose-Dependent Disposition of Sodium Arsenate in Mice Following Acute Oral Exposure.
Hughes, M. F. ;
Menache, M. ;
Thompson, D. J. ;
||ManTech Environmental Technology, Inc., Research Triangle Park, NC. ;Duke Univ. Medical Center, Durham, NC. Center for Extrapolation Modelling.;Health Effects Research Lab., Research Triangle Park, NC.
||EPA-68-02-4450 ;EPA-68-D2-0056; EPA/600/J-94/329;
Sodium inorganic compounds ;
Dose-response relationships ;
Acute exposure ;
Oral administration ;
Biological effects ;
MMA(Methylarsonic acid) ;
DMA(Dimethylarsonic acid) ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Several interpretive reviews on the effects of arsenic have suggested there is a threshold dose, at which toxic or carcinogenic effects change disproportionately with relatively small changes in the dose of arsenic. A threshold (nonlinear) response may be related in part to the potential saturation of arsenic methylation, which could lead to increases in the reactive trivalent arsenicals. Therefore, the objective of the present study was to examine the effect of dose on the in vivo disposition of arsenate after oral administration in mice. A refined chromatographic method was used to examine excretion of metabolites over several time points, and the degree of linearity of the various dose-response relationships was assessed.