Record Display for the EPA National Library Catalog


Main Title Rat and Human Visual-Evoked Potentials Recorded Under Comparable Conditions: A Preliminary Analysis to Address the Issue of Predicting Human Neurotoxic Effects from Rat Data.
Author Hudnell, H. K. ; Boyes, W. K. ; Otto., D. A. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/158;
Stock Number PB91-116095
Additional Subjects Toxicology ; Nervous system ; Rats ; Human ; Patterns ; Spatial distribution ; Reprints ; Visual evoked potentials ; Species specificity ; Predictive value of tests
Library Call Number Additional Info Location Last
NTIS  PB91-116095 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
A search was undertaken for contributions of sustained and transient visual elements to the rat visual-evoked potential (VEP) using procedures similar to those used in humans. Evoked potentials were recorded following either pattern-reversal or pattern-onset stimulation over a range of spatial frequencies, and following adaptation to a stationary grating of the same spatial frequency as the test stimulus. The initial VEP component, a positive peak labeled P1, was early in latency, larger at lower spatial frequencies, larger following pattern-reversal than pattern-onset stimulation, and not reduced in amplitude by adaptation to a stationary grating. These properties suggest that P1 reflects the activity of a transient, motion-perception visual subsystem. Subsequent in latency to P1 was a negative peak labeled N2 which was largest at intermediate spatial frequencies, larger following pattern-onset than pattern-reversal stimulation, and reduced in amplitude by adaptation to a stationary grating. These properties suggest that N2 reflects the activity of a pattern-perception visual subsystem.