||Effects of Murine Cytomegalovirus on Development: Lack of Interactions of Virus and Sodium Salicylate.
Francis, B. M. ;
Huang, Y. S. ;
Hartig, P. C. ;
Rosen, M. B. ;
Kawanishi., C. Y. ;
||Health Effects Research Lab., Research Triangle Park, NC. Developmental Toxicology Div. ;NSI Technology Services Corp., Research Triangle Park, NC.
Sodium salicylate ;
Pregnancy outcome ;
Plaque assay ;
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Interactions between exposure to xenobiotics and disease can occur during pregnancy. Few data are available on the consequences of such interactions on developmental parameters. In the study we investigated potential interactions between murine cytomegalovirus (MCMV), which induces embryolethality; and sodium salicylate, a known teratogen. MCMV administered on day 12 was embryotoxic over a broad range of doses from 2 times 10 to the third power to 2 times 10 to the sixth power plaque forming units, and also decreased postnatal weight gain. MCMV administration on day 8 of gestation caused significant prenatal mortality regardless of salicylate exposure. Salicylate did not cause fetal mortality or malformations at either 500 or 750 mg/kg/day on days 9 and 10 of gestation. No evidence of synergistic effects of MCMV and salicylate on embryo/fetal development were seen. (Copyright (c) by John Wiley & Sons, Ltd.)