||'Mycoplasma pneumoniae' Infection: Role of a Surface Protein in the Attachment Organelle.
Hu, P. C. ;
Cole, R. M. ;
Huang, Y. S. ;
Graham, J. A. ;
Gardner, D. E. ;
||Northrop Services, Inc., Research Triangle Park, NC. ;National Inst. of Allergy and Infectious Diseases, Bethesda, MD.;Health Effects Research Lab., Research Triangle Park, NC.
Infectious diseases ;
Mycoplasma pneumoniae ;
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Attachment of Mycoplasma pneumoniae to host cells by means of a specialized terminus initiates infection. Monoclonal antibodies to a surface protein (Pl) inhibit this process, and react with a region of the tip covered with peplomer-like particles. Since antibodies against the Pl protein are generated by natural and experimental infection and by immunization, the substance may be an important determinant of protective immunity.