Record Display for the EPA National Library Catalog


Main Title Fungicide Methyl 2-Benzimidazole Carbamate Causes Infertility in Male Sprague-Dawley Rats.
Author Carter, S. D. ; Hess, R. A. ; Laskey, J. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc./Environmental Sciences, Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/267;
Stock Number PB88-171079
Additional Subjects Toxicology ; Fungicides ; Laboratory animals ; Rats ; Reproduction(Biology) ; Fertility ; Reprints ; Carbendazim
Library Call Number Additional Info Location Last
NTIS  PB88-171079 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
A serial breeding technique was used to evaluate the fertility of male Sprague-Dawley rats after exposure to the fungicide carbendazim (methyl 2-benzimidazole carbamate)(C). Proven-fertile male rats (90 d old) received 10 daily doses of corn oil or C(400 mg/kg/d) peroral. Each male was bred with a new female each wk; breeding began on the third d of treatment and continued for 32 wks postexposure. Twelve d after each breeding period the females were killed, their uteri and fetuses were examined, & the number of dead and viable fetuses was determined. All males were killed 35 wks postexposure, & testicular tissue was prepared for histopathological examination by vascular perfusion. Fertility (% fertile as indicated by pregnant females) of males in the C-treated group was depressed during the first postexposure wk; 10 of the 24 treated males failed to breed, as compared with no breeding failures in the control group. By the 5th postexposure wk, 16 of the 24 C-treated males were infertile. Of these 16 males 4 recovered fertility after a failure to breed for 5 to 11 consecutive breeding periods.