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Main Title Chronic Toxicity of Dursban 'Chlorpyrifos' to the Fathead Minnow 'Pimephales promelas' and the Resultant Acetylcholinesterase Inhibition.
Author Jarvinen, A. W. ; Nordling, B. R. ; Henry, M. E. ;
CORP Author Environmental Research Lab.-Duluth, MN.
Year Published 1983
Report Number EPA-600/J-83-116;
Stock Number PB84-128123
Additional Subjects Toxicology ; Fishes ; Inhibition ; Exposure ; Acetylcholinesterase ; Survival ; Phosphorus organic compounds ; Reprints ; Dursban ; Fathead minnows ; Pimephales promelas ; Water pollution effects(Animals) ; Phosphorothioic acid/diethyl-(trichloro-pyridyl)
Library Call Number Additional Info Location Last
NTIS  PB84-128123 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Fathead minnows (Pimephales promelas) were exposed to Dursban during a chronic toxicity test for 200 days including a reproductive period of their life cycle. The fish concentrated Dursban approximately 1700 times. Survival of first-generation fish was adversely affected at 2.68 micrograms/liter within 60 days. A significant increase in deformities occurred at 2.68 micrograms/liter within 30 days. Growth was significantly reduced at 2.68 micrograms/liter within 30 days and at 1.21 micrograms/liter by 60 days. Maturation of the first-generation fish was reduced at all Dursban exposures and reproduction was significantly reduced at 0.63 micrograms/liter and above. Growth and estimated biomass of 30-day-old second-generation fish were significantly reduced at 0.12 micrograms/liter, the lowest concentration tested. Brain acetycholinesterase (AChE) activity was significantly inhibited at 0.27 micrograms/liter and above. AChE inhibition ranged from near 10% in fish exposed to 0.12 micrograms /liter to 89% for those exposed at 2.68 micrograms/liter. Inhibition results are compared to other results demonstrated during the chronic study. The use of exposure units (exposure concentration x exposure duration) is discussed as a tool for determining the effects of organophosphate pesticides on the environment.