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Main Title Tumors of the Central Nervous System, Volume 2 Gliomas: Glioblastoma (Part 2) / [electronic resource] :
Author Hayat, M.A.
Publisher Springer Netherlands,
Year Published 2011
Call Number RC261-271
ISBN 9789400706187
Subjects Medicine ; Oncology ; Radiology, Medical ; Neurosurgery ; Pathology
Internet Access
Description Access URL
Collation XXII, 458 p. online resource.
Due to license restrictions, this resource is available to EPA employees and authorized contractors only
Contents Notes
Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.