Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of the Herbicide 2,4-Dichlorophenyl(rho)-Nitrophenyl Ether (NIT) on Serum Thyroid Hormones in Adult Female Mice.
Author Gray jr, L. E. ; Kavlock, R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA/600/J-83-044;
Stock Number PB84-101500
Additional Subjects Herbicides ; Thyroid hormones ; Hormones ; Females ; Mice ; Parenteral infusions ; Dosage ; Nitrogen organic compounds ; Reprints ; Nitrogen ; Ether/(dichlorophenyl)-(nitrophenyl)
Library Call Number Additional Info Location Last
NTIS  PB84-101500 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 7p
The administration of the herbicide 2,4-Dichlorophenyl-p-nitrophenyl ether (nitrofen; NIT) to adult female mice by i.p. injection at doses of 500 and 1000 mg/kg/day for 3 days, reduced serum thyroxine (T4) levels. T4 levels were reduced in the high-dosage group by 60% of the control and by 20% in the low-dose group. Serum triiodothyronine (T3) levels were relatively unaffected by NIT treatment at either dose. The animals appeared euthyoid, as body weights were unaffected even though T4 levels were reduced. Liver weights were slightly higher as a result of NIT exposure at both 500 and 1000 mg/kg/day.