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RECORD NUMBER: 47 OF 80

Main Title Morphometric, Biochemical, and Physiological Assessment of Perinatally Induced Renal Dysfunction.
Author Kavlock, Robert J. ; Gray, Jacqueline ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-600/J-83-006;
Stock Number PB83-189084
Additional Subjects Toxicology ; Bioassay ; Rats ; Laboratory animals ; Embryos ; Reprints ; Renal dysfunction ; Chlorambucil ; Nitrofen ; Mercuric chloride
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NTIS  PB83-189084 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Abstract
Three chemicals, known either to alter renal development when administered during fetal development or to affect renal function when administered to adult rats, were administered to Sprague-Dawley rats at critical periods of renal development. Chlorambucil (CHL) was administered ip on d 11 of gestation at doses of 0.3 and 6 mg/kg; nitrofen (2,4-dichlorophenyl p-nitrophenyl ether) (NIT) was given po on d 8-16 of gestation at 0.4.17, 12.5, and 25 mg/kg.d and mercuric chloride (MER) was given sc on postnatal d 1 at 0.14, and 28 micrograms/pup. To assess the effects of these toxicants on the functional development of the kidneys, a diuresis test with and without antidiuretic hormone was applied on postnatal d 3 (PD 3); a hydropenia test on PD 6; and kidney weights, glomerular counts in midhilar cross sections, and the specific activity of renal alkaline phosphatase were determined on PD 3 and 6.