||Effects of the Benomyl Metabolite, Carbendazim, on the Hypothalamic-Pituitary Reproductive Axis in the Male Rat.
Goldman, J. M. ;
Rehnberg, G. L. ;
Cooper, R. L. ;
Gray, L. E. ;
Hein., J. F. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;NSI Technology Services Corp., Research Triangle Park, NC.
Hypothalamo-hypophyseal system ;
Pituitary hormone releasing hormones ;
Organ weight ;
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Carbendazim (MBC), the bioactive metabolite of the fungicide benomyl, has been reported to induce a number of testicular alterations in male rats. In order to broaden an exploration of its effects on the reproductive system, the present study focused on the possible presence of concurrent endocrine changes in the hypothalamic and pituitary components of the brain-pituitary-testicular axis. Subchronic administration of MBC (50, 100, 200 or 400 mg/kg) was found to cause a dose-related elevation in serum follicle-stimulating hormone (FSH) and pituitary luteinizing hormone (LH). Values for prolactin and thyroid-stimulating hormone remained unchanged. The effect on FSH was associated with fertility status and independent of serum testosterone. It may be linked to alterations in Sertoli cell-pituitary signaling. Changes in pituitary LH at 400 mg/kg were unrelated to fertility and suggest an influence of MBC on LH metabolism. (Copyright (c) 1989 Elsevier Scientific Publishers Ireland Ltd.)