||Effect of Ozone on Drug-Induced Sleeping Time in Mice Pretreated with Mixed-Function Oxidase Inducers and Inhibitors.
Graham, Judith A. ;
Menzel, Daniel B. ;
Miller, Frederick J. ;
Illing, Joseph W. ;
Gardner, Donald E. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Laboratory animals ;
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Studies were conducted to investigate the effect of ozone in prolonging pentobarbital (PEN)-induced sleeping time (S.T.). Since ozone is a common air pollutant, an ozone-induced alteration of mechanisms of drug action could have public health implications. It was shown that a 5-hr exposure to 1960 micrograms ozone/cu. m. (1 ppm) caused an increased PEN-induced S.T. in female mice (three strains), rats, and hamsters. This response was not observed in male rats or in male mice even when the latter were exposed for 5 hr/day for 3 days. Male hamsters were affected, but less so than females. These data are interpreted as a systemic effect of ozone on mechanisms of the termination of action of pentobarbital.