Record Display for the EPA National Library Catalog


Main Title Placental Transfer and Fetal Deposition of Hexachlorobenzene in the Hamster and Guinea Pig.
Author Courtney, K. D. ; Andrews, J. E. ; Grady, M. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/144;
Stock Number PB86-101805
Additional Subjects Toxicology ; Hamsters ; Guinea pigs ; Dosage ; Reprints ; Benzene/hexachloro ; Hexachlorobenzene
Library Call Number Additional Info Location Last
NTIS  PB86-101805 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Hexachlorobenzene (HCB) was administered at dose levels of 0, 1.0, 10.0, or 50.0 mg HCB/kg body wt by gavage to pregnant hamsters and guinea pigs for 6 days up to the time of liver development in the fetus. Samples of maternal fat, thymus, skin, liver, lung, brain, spleen, urinary bladder, muscle, plasma, and blood were analyzed for HCB concentration. Additionally, fetuses, placentas, and yolk sacs were analyzed for HCB content. HCB was found in all tissues assayed. The highest concentrations of HCB were found in the hamster tissues, with the hamster fetuses having a fivefold greater concentration of HCB than the guinea pig fetuses. Comparisons were made of the hamster and guinea pig data with similar data in the mouse and rat.