Record Display for the EPA National Library Catalog


Main Title Lung Model Casting Techniques for Interspecies Morphometric Comparisons.
Author Patra, A. L. ; Grady, M. A. ; Miller, F. J. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-68-02-4032; EPA-600/D-84-038;
Stock Number PB84-152867
Additional Subjects Lung ; Models ; Casting ; Respiratory system ; Comparison ; Laboratory animals ;
Library Call Number Additional Info Location Last
NTIS  PB84-152867 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 19p
Techniques have been developed for casting both solid and hollow lung models from lung specimens. These techniques have been used to make casts of rat, rabbit, baboon, and human lungs and may be used for other species. An air line at a positive pressure of 25 cm of water is connected to the trachea to air-dry lungs that have been surgically removed from the species. To make a solid model, silicone rubber is injected in to the dry lung. Solid models also can be made by injecting silicone rubber directly in situ using saline displacement techniques. Nasopharynx casts are made by direct injection of silicone rubber through the trachea. Using the lost wax technique, a hollow cast of the airways and the nasopharynx can be made. Anatomical differences in lungs and nasal passages have been observed among species. Current research investigates casting of the respiratory tract starting at the nares and extending through the larynx to the tracheobronchial tree.