Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effect of Sulfolane on Behavioral and Autonomic Thermoregulation in the Rat.
Author Gordon, C. J. ; Dyer, R. S. ; Long, M. D. ; Fehlner, K. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/521;
Stock Number PB88-170915
Additional Subjects Toxicology ; Thermoregulation ; Rats ; Laboratory animals ; Behavior ; Reprints ; Sulfolane
Library Call Number Additional Info Location Last
NTIS  PB88-170915 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 10p
In one study, colonic temperature, skin temperature and metabolic rate and, in another study, preferred ambient temperature (Ta) were measured over an 8 hr period in the Sprague-Dawley rat following an intraperitoneal injection of 800 mg/kg sulfolane or physiological saline. At Ta's of 15 and 25 C sulfolane caused a significant inhibition in metabolic rate and reduction in colonic temperature which lasted over the 8 hr measuring period. At both Ta's, metabolic rate tended to recover approximately 4 hr after sulfolane injection. Colonic temperature tended to recover with time but was still significantly reduced at 8 hr post-injection. Tail skin temperature was unaffected by sulfolane. Preferred Ta in the sulfolane-treated rat was not significantly different from the controls. Interestingly, in spite of their hypothermic condition, the sulfolane-treated animals did not select a warm Ta which would have elevated their body temperature to normal.