Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Sulfolane-Induced Hypothermia Enhances Survivability in Mice.
Author Gordon, C. J. ; Long, M. D. ; Fehlner, K. S. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/443;
Stock Number PB88-170931
Additional Subjects Hypothermia ; Survival ; Thermoregulation ; Mice ; Body temperature ; Physiological effects ; Laboratory animals ; Toxicology ; Reprints ; Sulfolane ; Toxic substances
Library Call Number Additional Info Location Last
NTIS  PB88-170931 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 8p
Mice injected intraperitoneally with sulfolane (tetrahydrothiophene-1, 1-dioxide) undergo a decrease in metabolic rate and body temperature. If given the opportunity, mice treated with sulfolane preferentially seek a cool ambient temperature. At a warm ambient temperature (35 C) neither metabolic rate nor body temperature are decreased by sulfolane. When given the LD50 dose of sulfolane, the percent mortality varies directly with ambient temperature. For example, at 35 C mortality is 75% whereas at 25 C mortality is only 8%. By undergoing an autonomically and behaviorally-mediated decrease in body temperature (i.e., regulated hypothermia), sulfolane-treated mice appear to enhance their chance of survival.