In the past 30 years there have been numerous studies on the patho-physiological effects of exposure to radiofrequency (RF) radiation. It is clear that the majority of these effects can be attributed to the thermogenic action of RF radiation. During exposure to RF radiation the thermoregulatory system activates heat dissipating motor responses in an attempt to maintain thermal homeostasis, similar to the response that occurs when an animal is subjected to elevated environmental temperatures. However, the data base on the thermoregulatory effects of RF radiation in experimental mammals and man appears to be insufficient to develop totally safe exposure guidelines for the general population. (Copyright (c) ISI ATLAS OF SCIENCE, 1988.)