Record Display for the EPA National Library Catalog


Main Title Effects of Metal Cations on Pituitary Hormone Secretion In vitro (Journal Version).
Author Cooper, R. L. ; Goldman, J. M. ; Rehnberg, G. L. ; McElroy, W. K. ; Hein, J. F. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/401;
Stock Number PB89-106439
Additional Subjects Nickel ; Cadmium ; Zinc ; Pituitary hormones ; Laboratory animals ; Secretion ; Prolactin ; Thyrotropin ; LH ; Toxicology ; Metals ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-106439 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
The purpose of the study was to determine, in vitro, the effects of nickel, cadmium, and zinc (50 microM) on both baseline and potassium chloride (KCl)-stimulated pituitary luteinizing hormone (LH), prolactin (Prl), and thyroid-stimulating hormone (TSH) release. Baseline and stimulated LH releases were unaffected by nickel and zinc; however, cadmium caused an increase in baseline LH secretion. Baseline Prl release was decreased by zinc, while cadmium resulted in increased release of the hormone. Stimulated Prl release was lower during exposure to zinc but unaltered by nickel and cadmium. Following exposure to zinc, a rebound in stimulated release was noted for all three hormones measured. These results showed that the metal cations tested did have a direct effect on pituitary hormone release at a dose lower than those reported to alter testicular function in vitro. Furthermore, the changes in pituitary hormone secretion varied depending upon the metal and hormone being evaluated. (Copyright (c) VCH Publishers, Inc.)