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Main Title Effect of Inhaled Methanol on Pituitary and Testicular Hormones in Chamber Acclimated and Non-Acclimated Rats.
Author Cooper, R. L. ; Mole, M. L. ; Rehnberg, G. L. ; Goldman, J. M. ; McElroy, W. K. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Reproductive Toxicology Branch. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/064;
Stock Number PB92-150788
Additional Subjects Pituitary hormones ; Carbinols ; Testis ; Toxicity ; Respiration ; Prolactin ; Reproduction(Biology) ; Testosterone ; LH ; FSH ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-150788 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Two experiments were conducted to evaluate the effects of methanol (MEOH) on the serum hormones associated with reproductive function in the male rat. First, rats were exposed to MEOH for 6 hs and killed immediately or 24 hs later. The effect of the handling associated with placing the rat in the exposure chamber was also evaluated by comparing hormonal changes in sham- and MEOH-exposed groups acclimated (A) for two weeks with groups that were not acclimated (N-A). At 6 h, serum LH in sham-exposed, NA rats was significantly greater than in sham-exposed, A rats. 5,000 ppm MEOH significantly reduced serum LH in the N-A rats, while 10,000 ppm significantly increased serum LH in the A rats. Serum FSH and testosterone (T) were not different at 6 h. At 24 h, serum LH in A rats exposed to 10,000 ppm MEOH was greater than sham-exposed rats. Also, concentrations of serum and interstitial fluid (IF) T in the N-A rats at 24 h was generally greater than that observed in A rats. Serum and IF T in the A rats exposed to 10,000 ppm was lower, while serum and IF T in N-A rats was greater after exposure to 5,000 ppm and 10,000 ppm, respectively. In a second experiment, groups of A and N-A rats were exposed to 5000 ppm MEOH for 1, 2 or 6 h and killed immediately. Serum LH, T and corticosterone concentrations in sham- and MEOH-exposed rats were similar at all time points. However, the concentrations of LH and T in the N-A rats were greater than A rats after 1 and 6 h exposure, while that of corticosterone was greater at 1 and 6 h.