Record Display for the EPA National Library Catalog


Main Title Developmental Neurotoxicity: Evaluation of Testing Procedures with Methylazoxymethanol and Methylmercury.
Author Goldey, E. S. ; O'Callaghan, J. P. ; Stanton, M. E. ; Barone, S. ; Crofton, K. M. ;
CORP Author ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher cOct 94
Year Published 1994
Report Number EPA-68-D2-0056; EPA/600/J-94/527;
Stock Number PB95-148896
Additional Subjects Embryo development ; Toxicity ; Methylmercury compounds ; Methylazoxymethanol acetate ; Teratogens ; Nervous system ; Rats ; Glial fibrillary acidic protein ; Brain ; Organ weight ; Audiometry ; Startle reaction ; Motor activity ; Cognition ; Conditioned responses ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB95-148896 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 20p
Testing procedures for identification of potential developmental neurotoxicants were evaluated using two prototypical developmental neurotoxicants, methylazoxymethanol (MAM) and methylmercury (MeHg). A number of endpoints in the testing strategy were sensitive to the effects of prenatal exposure to MAM (30 mg/kg on Gestation Day (GD) 15): (1) MAM caused reduced neonatal body weights but did not affect viability or postnatal survivorship; (2) measurement of total and regional brain weight and histological analysis showed that a number of regions, the cortex and hippocampus in particular, were affected by MAM exposure; (3) an assay for glial fibrillary acidic protein (GFAP) showed that the concentration of this protein was significantly increased in the cortex and hippocampus of treated offspring; (4) a T-maze delayed-alternation procedure indicated that MAM-treated pups were slower in the acquisition phase of the task relative to control pups; (5) motor activity testing revealed hyperactivity in treated offspring that persisted into adulthood; and (6) acoustic startle procedures revealed reduced startle amplitudes in preweanlings.