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Main Title Risk assessment of complex mixtures /
Author Gibb, Herman J. ; Gibb, H. J. ; Chen, C. W.
Other Authors
Author Title of a Work
Chen, Chao W.
CORP Author Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1984
Report Number EPA-600/D-84-186
Stock Number PB84-223478
OCLC Number 70515222
Subjects Water--Analysis--Mathematical models ; Hazardous substances--Risk assessment ; Water--Pollution--Mathematical models ; Carcinogens--Environmental aspects--Measurement
Additional Subjects Effluents ; Epidemiology ; Assessments ; Carcinogenesis ; Risk assessment
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-D-84-186 Headquarters Library/Washington,DC 07/06/2010
NTIS  PB84-223478 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation [20] leaves : ill. ; 28 cm.
Quantitative carcinogenic assessment of complex mixtures is complicated by the variability of the mixtures. Different samples of effluents from the same source may vary in their carcinogenic potency. A multiplicative effect could be produced by the action of different fractions of a mixture on different stages of the carcinogenic process. A mathematical formula explaining this multiplicative effect is presented here. Antagonism may result from the action of different fractions on the same stage. Actual data from both epidemiologic studies and animal investigations are used for illustration.
Caption title. "EPA-600/D-84-186". "PB84-223478". Includes bibliographical references (leaves [11]-[14]). Photocopy.