| Main Title |
Review of the Mutagenicity of Ethylene Oxide. |
| Author |
Dellarco, V. L. ;
Generoso, W. M. ;
Sega, G. A. ;
Fowle, J. R. ;
Jacobson-Kram, D. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Oak Ridge National Lab., TN. Biology Div. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/550; |
| Stock Number |
PB92-124569 |
| Additional Subjects |
Mutagens ;
Ethylene oxide ;
Toxicology ;
Deoxyribonucleic acids ;
Risk assessment ;
Alkylating agents ;
Mutations ;
Cultured cells ;
Chromosomes ;
Linkage(Genetics) ;
Lethal genes ;
Dominant genes ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-124569 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
21p |
| Abstract |
Ethylene oxide has been shown to be an effective mutagen in a variety of organisms ranging from bacteria to mammalian cells. There is also an association between ethylene oxide exposure and human somatic cell cytogenetic damage. Furthermore, ethylene oxide has been shown to alkylate protein and DNA at exposure levels that have been encountered occupationally. Ethylene oxide is not only effective at producing somatic cell mutations but also at inducing genetic damage in germ cells. While it is clear that ethylene oxide is a germ cell mutagen in whole mammals, the mechanism(s) by which it produces genetic lesions in germ cells is uncertain. (Copyright (c) 1990 Wiley-Liss, Inc.) |
