| Main Title |
Evaluation of mutagenic effects of diesel emissions : I. tests for heritable and germ-cell effects in the mouse / |
| Author |
Russell, L. B. ;
Generoso, W. M. ;
Russell, W. L. ;
Oakberg, E. F.
|
| Other Authors |
|
| CORP Author |
Oak Ridge National Lab., TN.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
U.S. Environmental Protection Agency, Health Effects Research Laboratory, |
| Year Published |
1981 |
| Report Number |
PB81-235814; EPA-600/1-81-056; EPA-79-DX-0710 |
| Stock Number |
PB81-235814 |
| OCLC Number |
758900825 |
| Subjects |
Diesel motor exhaust gas--Physiological effect ;
Mutagenicity testing
|
| Additional Subjects |
Exhaust emissions ;
Mutagens ;
Toxicology ;
Evaluation ;
Mice ;
Bioassay ;
Exposure ;
Laboratory animals ;
Respiration ;
Air pollution ;
Mutagenesis ;
Diesel engine exhaust ;
Air pollution effects(Animals)
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| ELCD |
EPA 600-1-81-056 |
|
NVFEL Library/Ann Arbor, MI |
10/31/2011 |
| NTIS |
PB81-235814 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
vii, 26 p. : charts ; 28 cm. |
| Abstract |
The Environmental Protection Agency, under the Clean Air Act, is charged with the responsibility for regulating the emissions from new motor vehicles. In order to assess potential heritable effects of diesel exhaust, mice were exposed to whole diesel exhaust by inhalation and a number of genetic end points were studied. Exposure times varied from 5 to 10 weeks for the different groups. The diesel particulate concentration averaged 6 mg/cu. m. during the exposure period of 8 hours per day and 7 days of the week. The results of all genetic assays in both sexes were negative; however, small but unequivocal effects on the reproductive performance of females of one strain were observed. |
| Notes |
Includes bibliographical references. "PB81-235814." "Aug 81"--Cover. "EPA-600/1-81-056"--T.p. "Contract No. EPA-D-X0710"--T.p. "EPA Project Manager and Technical Project Officer: Larry Claxton"--T.p. "EPA Technical Project Officers for Exposure: John Orthoefer and Michael Pereira"--T.p. "ORNL Project Manager and Technical Project Officer: Laine B. Russell"--T.p. "This study was conducted in cooperation with the Department of Energy at the Oak Ridge National Laboratory interagency agreement DOE No. 40-728-78"--T.p. |
| Contents Notes |
The Environmental Protection Agency, under the Clean Air Act, is charged with the responsibility for regulating the emissions from new motor vehicles. In order to assess potential heritable effects of diesel exhaust, mice were exposed to whole diesel exhaust by inhalation and a number of genetic end points were studied. Exposure times varied from 5 to 10 weeks for the different groups. The diesel particulate concentration averaged 6 mg/mp3s during the exposure period of 8 hours per day and 7 days of the week. The results of all genetic assays in both sexes were negative; however, small but unequivocal effects on the reproductive performance of females of one strain were observed. |
