Record Display for the EPA National Library Catalog

RECORD NUMBER: 12 OF 32

OLS Field Name OLS Field Data
Main Title Enhanced Binding of Autologous Red Cells to the Macrophage Plasma Membrane as a Sensitive Indicator of Pollutant Damage.
Author Hadley, J. G. ; Gardner, D. E. ; Coffin, D. L. ; Menzel., D. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Clinical Studies Div. ;Duke Univ. Medical Center, Durham, N.C.
Year Published 1977
Report Number EPA/600/J-77/095;
Stock Number PB-278 595
Additional Subjects Erythrocytes ; Phagocytes ; Toxicity ; Immunity ; Lung ; Air pollution ; Immunology ; Toxicology ; Blood cells ; In vitro analysis ; Air pollution effects(Animals) ; Macrophages
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB-278 595 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 14p
Abstract
The alveolar macrophage (AM) represents the primary line of defense in host protection against inhaled infectious organisms. Following exposure to oxidant gases, the ability of the host to resist airborne bacterial infection is severely impaired, and damage to the AM defense system may be an important factor in increased susceptibility. Oxidant exposure could diminish the phagocytic capability of the macrophage system by either altering the phagocytic process per se (i.e., engulfment and digestion) or acting on cell surface structures responsible for the recognition and binding of material to the phagocyte. So that possible damage by oxidant exposure on the AM recognition mechanisms could be investigated, macrophages were isolated from rabbits and treated with a commercial preparation of wheat germ lipase. Preliminary evidence suggests that the oxidants increase the binding of wheat germ agglutinin (WGA) to the macrophage surface.