| Main Title |
Respirable particles and mists in mouse pulmonary infectivity model : effect of chronic or intermittent exposure / |
| Author |
Bradof, Jeannie.
|
| Other Authors |
|
| Publisher |
U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory, |
| Year Published |
1978 |
| Report Number |
EPA-600/1-78-036; EPA-68-02-1717 |
| Stock Number |
PB 284 904 |
| OCLC Number |
52473316 |
| Subjects |
Respiratory infections--Environmental aspects ;
Carbon--Health aspects
|
| Additional Subjects |
Carbon ;
Respiratory infections ;
Immunity ;
Toxicology ;
Sulfuric acid ;
Mice ;
Hamsters ;
Laboratory animals ;
Experimental data ;
Exposure ;
Antibodies ;
Resistance ;
Tables(Data) ;
Histology ;
Pathology ;
Bacterial diseases ;
Viral diseases ;
Lethal dosage ;
Bioassay ;
Concentration(Composition) ;
Mist ;
Lung ;
Streptococcus ;
Mortality ;
Environmental health ;
Animal models ;
Immunoglobins ;
Air pollution effects(Animals) ;
Toxic substances ;
Histopathology
|
| Internet Access |
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| EJBD |
EPA 600-1-78-036 |
|
Headquarters Library/Washington,DC |
04/22/2014 |
| EKBD |
EPA-600/1-78-036 |
|
Research Triangle Park Library/RTP, NC |
06/20/2003 |
| ELBD ARCHIVE |
EPA 600-1-78-036 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
| ELBD RPS |
EPA 600-1-78-036 |
repository copy |
AWBERC Library/Cincinnati,OH |
10/17/2014 |
| NTIS |
PB-284 904 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
x, 82 p. : ill. ; 28 cm. |
| Abstract |
The effects of respirable-sized sulfuric acid mist or mixtures containing acid mist and carbon particles (A-C) on the susceptibility to bacterial and viral respiratory infection were studied in mice and hamsters. Both species showed mortalities upon single 3-hour exposure to 600 mg/cu m but not 400 mg/cu m acid mist. Scanning electron microscopic examination indicated that the most severe changes, including emphysemic-like areas in alveoli, were found after five daily 3-hour exposures to 200 mg/cu m A-C. Significantly increased mortality and decreased bacterial clearance from lungs were also observed in mice challenged with Streptococcus sp. Significantly increased mortality and pulmonary consolidation, with concomitant decreased survival time, occurred in mice challenged with influenza virus aerosol and exposed to 50 mg/cu m A-C, 3 hr/day, 5 days/week for 4 weeks. Depressed secondary immune responses, as measured by serum antibody levels, were observed in various groups of vaccinated mice exposed to pollutant. The effects of long-term exposure to mixtures of approximately 1.4 mg/cu m sulfuric acid mist and 1.5 mg/cu m carbon particles as well as carbon only were determined. Significant alterations of immunoglobulin concentration, depression of primary antibody response in spleen cells and decreased resistance to respiratory infection as measured by mortality, survival time, and pulmonary consolidation after 20 weeks of exposure were evident. |
| Notes |
"Project officer, Donald E. Gardner." IIT Research Institute "May 1978." "EPA-600/1-78-036." Includes bibliographical references. |
