Record Display for the EPA National Library Catalog


Main Title Influence of Exposure Patterns of Nitrogen Dioxide and Modifications by Ozone on Susceptibility to Bacterial Infectious Disease in Mice.
Author Graham, J. A. ; Gardner, D. E. ; Blommer, E. J. ; House, D. E. ; Menache, M. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/162;
Stock Number PB88-151659
Additional Subjects Nitrogen dioxide ; Ozone ; Bacterial diseases ; Infectious diseases ; Mice ; Laboratory animals ; Exposure ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB88-151659 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
The nitrogen dioxide (NO2) diurnal cycle found in urban communities usually consists of a low basal concentration upon which are superimposed higher concentration peaks or spikes of short duration. Various components of the environmental exposure mode were examined to assess effects of urban exposure profiles on susceptibility to infectious pulmonary disease. Mice were exposed to NO2 peaks of 4.5 ppm for 1, 3.5, or 7 h, challenged with Streptococcus sp. either immediately or 18 h postexposure, and then observed for mortality. When the streptococcal challenges were immediately after NO2 exposure, the mortality rate was directly related to the length of peak exposure, whether or not a basal exposure was used, and all peak lengths significantly increased mortality. When the challenge was delayed for 18 h after the peak exposure, spiked exposure, of 3.5 and 7 h increased mortality to the same degree. If a 1-h peak exposure to 4.5 ppm was superimposed twice daily upon a continuous basal NO2 concentration of 1.5 ppm, there was a suggestive trend toward increased mortality near the end of the second week of exposure when challenge occurred immediately after the morning spike.