Record Display for the EPA National Library Catalog
RECORD NUMBER: 47 OF 284| Main Title | Comparative Gastrointestinal Enzyme Activity and Activation of the Promutagen 2,6-Dinitrotoluene in Male CD-1 Mice and Male Fischer 344 Rats. | |||||||||||
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| Author | Chadwick, R. W. ; George, S. E. ; Chang, J. ; Kohan, M. J. ; Dekker., J. P. ; | |||||||||||
| CORP Author | Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. | |||||||||||
| Publisher | c1990 | |||||||||||
| Year Published | 1990 | |||||||||||
| Report Number | EPA/600/J-90/169; | |||||||||||
| Stock Number | PB91-115816 | |||||||||||
| Additional Subjects | Enzymes ; Gastrointestinal system ; Mutagens ; Toxicology ; Mice ; Rats ; Male ; Hepatuma ; In vitro analysis ; In vivo analysis ; Metabolism ; Bioassay ; Reprints ; Ditoluenes ; Species specificity ; Biotransformation ; Mutagenicity tests ; Carcinogenicity tests | |||||||||||
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| Collation | 9p | |||||||||||
| Abstract | Comparative intestinal nitroreductase, azo reductase, beta-glucuronidase, dechlorinase, and dehydrochlorinase activities in young male Fischer 344 rats and young male CD-1 mice were measured in vitro while the comparative biotransformation of 2, 6-dinitrotoluene to mutagenic metabolites was determined in vivo. The mice, which exhibit a high spontaneous incidence of hepatomas, had markedly greater nitroreductase activity and metabolized significantly more 2, 6-dinitrotoluene to mutagenic metabolites than did Fischer 344 rats, which show a low incidence of liver tumors. Results of this study indicate that species differences in the incidence of hepatomas may be influenced by microbial flora and/or the biotransformation of xenobiotics in the G.I. tract. (Copyright (c) Elsevier Scientific Publishers Ireland, Ltd.) |