| Main Title |
Amphetamine-, Scopolamine-, and Caffeine-Induced Locomotor Activity Following 6-Hydroxydopamine Lesions of the Mesolimbic Dopamine System. |
| Author |
Joyce, Eileen M. ;
Koob, George F. ;
|
| CORP Author |
Salk Inst., San Diego, CA. Arthur Vining Davis Center for Behavioral Neurobiology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1981 |
| Report Number |
EPA-R-806777; EPA-600/J-81-578; |
| Stock Number |
PB82-247990 |
| Additional Subjects |
Dopamine ;
Amphetamines ;
Scopolamine ;
Caffeine ;
Drugs ;
Rats ;
Laboratory animals ;
Toxicity ;
Reprints ;
Locomotor activity ;
Lesions ;
Dopamine/hydroxy
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-247990 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
5p |
| Abstract |
As previously reported, 6-hydroxydopamine (6-OHDA) lesions to the region of the nucleus accumbens blocked the locomotor activation induced by low doses of d-amphetamine, and produced a supersensitive locomotor response to the dopamine (DA) agonist, apomorphine. This same lesion, however, failed to block the locomotor activation induced by scopolamine of caffeine. These results suggest that scopolamine and caffeine activate locomotion in the rat by acting independently of presynaptic terminals in the mesolimbic DA system. |
