Record Display for the EPA National Library CatalogRECORD NUMBER: 3 OF 4
|Main Title||Mutagenesis and Morphological Transformation of Mammalian Cells by a Non-Bay-Region Polycyclic Cyclopenta(cd)pyrene and Its 3,4-Oxide1.|
|Author||Gold, Avram ; Nesnow, Stephen ; Moore, Martha ; Garland, Helen ; Curtis, Gaynelle ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Toxicology ; Cells(Biology) ; Morphology ; Mammals ; Cultures(Biology) ; Mutations ; Nitrogen organic compounds ; Reprints ; Cyclopentapyrene ; Mutagenesis ; Toxic substances ; Cell cultures ; Metabolites ; Cyclopentapyrene oxide|
Cyclopenta(cd)Pyrene, a constituent of environmental emissions, has been found to mutate and transform mammalian cells in culture. Cyclopenta(cd)pyrene 3,4-oxide, a presumed metabolite, was found to a be direct-acting mutagen and to transform mammalian cells. These results suggest that cyclopenta(cd)pyrene 3,4-oxide may be an ultimate mutagenic form of the parent hydrocarbon.