||Toxicological Evaluation of Complex Industrial Wastes Implications for Exposure Assessment/
DeMarini, D.M. ;
Gallagher, J. E. ;
Houk, V. S. ;
Simmons, J. E.
||Health Effects Research Lab., Research Triangle Park, NC.
||U. S. Environmental Protection Agency, Office of Research and Development.
Industrial wastes ;
Hazardous materials ;
Deoxyribonucleic acids ;
Salmonella typhimurium ;
Mutagenicity tests ;
Metabolic activation ;
||Some EPA libraries have a fiche copy filed under the call number shown.
||18p. 28 cm.
A variety of short-term bioassays to construct a battery of tests that could be used for assessing the biological effects of potentially hazardous complex industrial wastes were evaluated. Ten samples were studied for hepatotoxicity: These samples and an additional five were studied for mutagenicity. Although the data are limited to these samples, the results suggest that the Salmonella assay (either TA98 or TA100) or a prophage-induction assay (both in the presence of S9) in combination with determination of relative liver weight and levels of a set of serum enzymes in rats would provide a battery of tests suitable to characterize complex industrial wastes for mutagenic and hepatotoxic potential. The biological activities exhibited by the wastes were not readily predicted by the chemical profiles of the wastes, emphasizing the importance of characterizing potentially hazardous complex industrial wastes by both chemical and biological means. (Copyright (c) Elsevier Science Publishers B.V. (Biomedical Division.))
"Submitted to: Toxicology Letters; Vol. 49; pp. 199-214; 10/89." "15 October 1978." Bibliography: leaves 178-182.