Record Display for the EPA National Library Catalog


Main Title Selective Immunotoxic Effects in Mice Treated with the Adenosine Deaminase Inhibitor 2-Deoxycoformycin (Journal Version).
Author Luebke, R. W. ; Lawson, L. D. ; Rogers, R. R. ; Riddle, M. M. ; Rowe, D. G. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/395;
Stock Number PB89-105688
Additional Subjects Immunity ; Toxicity ; Toxic substances ; Adenosine deaminase ; Natural killer cells ; Spleen ; Immunosuppression ; Laboratory animals ; Deoxyribonucleosides ; Nucleosides ; Body weight ; Reprints ; Deoxycoformycin ; CAS 53910-25-1
Library Call Number Additional Info Location Last
NTIS  PB89-105688 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Mice given the adenosine deaminase inhibitor 2-deoxycoformycin, for five days were evaluated 24 h, 72 h and 6 days after the final dose. Spleen weight was decreased for up to 6 days after treatment. The number and relative percentage of circulating lymphocytes were decreased 24 and 72 h after the last injection. Lymphoproliferative responses to T cell mitogens were suppressed for at least 72 h post-treatment, whereas the mixed lymphocyte response was normal at 24 h but was depressed at 72 h post-treatment. Natural killer (NK) cell activity was greater in treated mice than in controls for the entire observation period. The antibody responses of mice, treated with 2 or 4 microgram 2dCF/g over four days prior to or after immunization with sheep erythrocytes, were suppressed or enhanced, respectively, compared to controls. The results indicate selective effects of 2dCF on immune function and suggest that subpopulations of lymphocytes differ in the degree of sensitivity to 2dCF.