Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Studies on the Percutaneous Absorption of Parathion and Paraoxon. I. Hydrolysis and Metabolism Within the Skin.
Author Fredriksson, Torsten ; Farrior, Jr., William L. ; Witter., Robert F. ;
CORP Author Communicable Disease Center, Atlanta, Ga.
Year Published 1961
Stock Number PB-280 014
Additional Subjects Pesticides ; Insecticides ; Toxicology ; Metabolism ; Absorption(Biology) ; Skin(Anatomy) ; Laboratory animals ; Cats ; Rats ; Rabbits ; Hydrolysis ; Reprints ; Toxic substances ; Parathion ; Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester)
Library Call Number Additional Info Location Last
NTIS  PB-280 014 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 9p
The ability of the skin of man, cat, rabbit, and rat to hydrolyze or otherwise metabolize paraoxon (E 600, or diethyl 4-nitrophenyl phosphate) or parathion (E 605, or diethyl 4-nitrophenyl thiononophospate) was investigated using the Warburg technique and paper chromatography. Parathion was not hydrolyzed or transformed into paraoxon by the skin of any of the species tested. Paraoxon, on the other hand, was hydrolyzed by skin from man, cat, and rabbit. This reaction, which was enzyme in nature, occurred at the fastest rate in the rabbit. In this tissue, about 20 percent of the paraoxon was hydrolyzed in 1 hour by 1 gram of skin at 25C, while only about one percent was converted by skin from man or cat. The relation of these findings to the percutaneous absorption of these compounds was discussed.