| Main Title |
Some Research Needs to Support Mutagenic Risk Assessments from Whole Mammal Studies. |
| Author |
Jackson, Ernest R. ;
Fowle, III, John R. ;
Voytek, Peter E. ;
|
| CORP Author |
Environmental Protection Agency, Washington, DC. Reproductive Effects Assessment Group. |
| Year Published |
1982 |
| Report Number |
EPA-600/D-82-322; |
| Stock Number |
PB82-234279 |
| Additional Subjects |
Mammals ;
Toxicology ;
Dosage ;
Responses ;
Bioassay ;
Genetics ;
Laboratory tests ;
Deoxyribonucleic acids ;
Estimates ;
Risk assessments ;
Mutagenesis
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-234279 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
20p |
| Abstract |
This paper presents an approach to use DNA binding data to obtain information as to the possible shape of the dose response curve at low chemical exposure levels in whole mammals. Such information will be useful for both mutagenic and carcinogenic risk estimations in which high to low dose extrapolations are necessary. The paper also discusses the uses of genetic damage tests that can be performed in both humans and experimental mammals and how these tests may be useful in estimating mutagenic risks. |
