||Dermal Absorption of Pesticides Calculated by Deconvolution.
Fisher, H. L. ;
Most, B. ;
Hall, L. L. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Blood analysis ;
Isotopic labeling ;
Environmental health ;
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Using published human data on skin-to-urine and blood-to-urine transfer of 12 pesticides and herbicides, the skin-to-blood transfer rates for each compound were estimated by two numerical deconvolution techniques. Regular constrained deconvolution produced an estimated upper limit on cumulative dermal absorption of the radiolabel, while minimized deconvolution produced an upper bound on cumulative dermal absorption of parent compound. Dermal absorption rate was largest within 8 h of dosing for all pesticides examined. The deconvolution technique described here permits the calculation of the temporal aspect of dermal absorption for linear systems.