Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Measurement of Cardiopulmonary Function by Rebreathing Methodology in Piglets.
Author Mentz, W. M. ; Lawson, E. E. ; Friedman, M. ;
CORP Author North Carolina Univ. at Chapel Hill.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/377;
Stock Number PB86-210622
Additional Subjects Swine ; Laboratory animals ; Measurement ; Reprints ; Cardiopulmonary function ; Rebreathing
Library Call Number Additional Info Location Last
NTIS  PB86-210622 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 7p
The use of a multiple gas rebreathing method for the measurement of cardiopulmonary function in mechanically ventilated neonates was evaluated. The following indices of cardiopulmonary function were assessed in 20 piglets (mean weight, 2.3 kg): (1) pulmonary capillary blood flow (Q), (2) diffusing capacity for carbon monoxide (DLCO), (3) lung gas volume (FRC), (4) oxygen consumption (VO2), and (5) volume of the pulmonary tissues and capillaries (VTPC), the latter an estimate of total lung water. During mechanical ventilation at zero end expiratory pressure, all rebreathing parameters correlated well with body weight. Additionally, a good correlation (r = 0.81, slope = 0.99) between VTPC and postmortem estimate of total lung water was observed. The effect of ventilation with positive end expiratory pressure (PEEP) was then studied in 10 piglets.