Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Dermal Absorption of Pesticides Calculated by Deconvolution.
Author Fisher, H. L. ; Most, B. ; Hall, L. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/194;
Stock Number PB86-120342
Additional Subjects Pesticides ; Dermatology ; Toxicology ; Absorption ; Herbicides ; Urine ; Blood analysis ; Isotopic labeling ; Reprints ; Environmental health ; Deconvolution
Library Call Number Additional Info Location Last
NTIS  PB86-120342 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 16p
Using published human data on skin-to-urine and blood-to-urine transfer of 12 pesticides and herbicides, the skin-to-blood transfer rates for each compound were estimated by two numerical deconvolution techniques. Regular constrained deconvolution produced an estimated upper limit on cumulative dermal absorption of the radiolabel, while minimized deconvolution produced an upper bound on cumulative dermal absorption of parent compound. Dermal absorption rate was largest within 8 h of dosing for all pesticides examined. The deconvolution technique described here permits the calculation of the temporal aspect of dermal absorption for linear systems.