||Dermal absorption and pharmacokinetics of pesticides in rats /
Shah, P. V. ;
Fisher, H. L. ;
Sumler, M. R. ;
Hall, L. L.
||Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
|| U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory ; Reproduced by National Technical Information Service,
In vivo analysis ;
Skin absorption ;
Tissue distribution ;
Polychlorobiphenyl compounds ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||20 pages ; 28 cm
Dermal absorption and disposition of carbaryl, carbofuran, chlordecone, hexachlorobiphenyl and dinoseb were studied in female Fischer 344 rats. Acetone solution on the (14)C labeled pesticide was applied to a previously clipped mid-dorsal region of the back. At various time intervals, animals were killed and selected organs were analyzed for radioactive (14)C content. A physiological compartmental model was fitted to the skin penetration, tissue distribution, and excretion data. The equilibrium tissue to blood ratios and excretion rate constants and skin absorption rate were determined from the model. In many cases, differences in kinetics and retention were found between young and adult rats. The dermal penetration function was single or biexponential, requiring a one or two compartmental model for simulating the skin penetration process. (Copyright (c) 1989 American Chemical Society.)
"PB90-263302." "EPA/600/D-90/128." Microfiche.