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Main Title Short-term screening test for quick responses to pollutants where health effects data are lacking {microform} /
Author Drummond, John G. ; Fenters, James D. ; Ehrlich, Richard ; Aranyi, Catherine ; Schiff, Leonard J.
Other Authors
Author Title of a Work
Drummond, John G.
CORP Author IIT Research Inst., Chicago, IL. Life Sciences Research Div.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1982
Report Number EPA/600/1-82/004; EPA-68-02-2088
Stock Number PB82-234303
Subjects Environmental health--United States ; Pollution--United States--Physiological effect
Additional Subjects Screenings ; Toxicology ; Sulfates ; Aerosols ; Physiological effects ; Air pollution ; Exposure ; Respiration ; Sensitivity ; Concentration(Composition) ; Mice ; Laboratory animals ; Bacteria ; Mortality ; Bioassay ; Air pollution effects(Animals) ; Streptococcus pyogenes
Library Call Number Additional Info Location Last
NTIS  PB82-234303 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 41 p. ; 28 cm.
Results of assessment of various health effects parameters were correlated to determine which tests were the most sensitive indicators of toxic effects of exposure to sulfate aerosols. Inhalation studies were conducted involving single 3-hr exposure to various concentrations of cupric sulfate (0.43 - 2.64 mg/cu m), aluminum sulfate (1.65 - 2.75 mg/cu m), and aluminum ammonium sulfate (1.47 - 3.81 mg/cu m); and multiple 5 or 10 daily 3-hr exposures to cupric sulfate (0.1 mg/cu m). The test parameters studied in CD1 mice were changes in mortality after respiratory infection with Streptococcus pyogenes; pulmonary bactericidal activity; pulmonary cell number, type, viability, and ATP content; and pulmonary morphology by scanning electron microscopy. Trachael ciliary beating frequency and morphology were also studied in both CD1 mice and Syrian golden hamsters.
Caption title. "August 1982." "EPA-600/1-82-004." Microform.