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Main Title Health effects of fine- and coarse-mode particulate matter : exposures by inhalation and intratracheal instillation /
Author Aranyi, C. ; Drummond, J. ; Ehrlich, R. ; Fenters, J. D. ; Graf, J.
Other Authors
Author Title of a Work
Aranyi, Catherine.
CORP Author IIT Research Inst., Chicago, IL.;Health Effects Research Lab., Research Triangle Park, NC. ;International Research and Development Corp., Mattawan, MI.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1984
Report Number EPA 600-D-84-111; EPA-R-806327
Stock Number PB84-201656
OCLC Number 12645448
Subjects Air--Pollution--Physiological effect
Additional Subjects Toxicology ; Inhalation ; Aerosols ; Air pollution effects(Animals) ; Particulates
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-D-84-111 Headquarters Library/Washington,DC 01/09/2020
ELBD ARCHIVE EPA 600-D-84-111 In Binder Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-D-84-111 AWBERC Library/Cincinnati,OH 04/10/1998
NTIS  PB84-201656 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 3 pages ; 28 cm
Because coarse mode particles are rarely studied in their existing size ranges (greatest mass about 5-7 micrometers, aerodynamic diameter), the authors investigate the effects of four such particles, quartz, ferric oxide, calcium carbonate, and sodium feldspar, on host defenses against bacterial pulmonary infection. Mice which received intratracheal instillations of 10, 33, and 100 micrograms/mouse were exposed within an hour to aerosols of viable Streptococcus, and pneumonia-induced mortality was measured. At 33 and 100 micrograms/mouse, all particles significantly increased mortality. At the lower dose, only Fe203 caused a significantly increase in mortality. To evaluate potential delayed effects, mice were challenged with the bacteria 24 h after exposure to 100 micrograms particles/mouse. Delaying the challenge did not significantly alter the response, except for the sodium feldspar group for which a partial recovery was observed.
Caption title. At head of title: Environmental research brief. "May 1984." "EPA 600-D-84-111."