Record Display for the EPA National Library Catalog


Main Title Pulmonary Function Adaptation to Ozone in Subjects with Chronic Bronchitis.
Author Kulle, T. J. ; Milman, J. H. ; Sauder, L. R. ; Kerr, H. D. ; Farrell, B. P. ;
CORP Author Maryland Univ. at Baltimore. Dept. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-807262; EPA/600/J-84/376;
Stock Number PB86-220431
Additional Subjects Ozone ; Smoking ; Respiratory systems ; Bronchitis ; Exposure ; Sensitivity ; Reprints ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB86-220431 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Twenty smokers with chronic bronchitis were exposed to 0.41 ppm ozone for 3 hr-day for 5 consecutive days and reexposed 4 days later to determine (1) if they are sensitive to ozone, (2) if they adapt, and (3) if the adaptation lasts longer than 4 days. There were significant decrements in forced vital capacity (FVC) and forced expiratory volume in 3 sec (FEV3) on the first day of the 5-day repeated exposures and also on reexposure 4 days following cessation of the sequential exposures. Symptoms experienced were mild and did not predominate on any exposure days. These results suggest that individuals with chronic bronchitis adapt rapidly to ozone and lose the adaptive phenomenon within 4 days. The small decreases seen in FVC and FEV3 appear to impose no more than minimal limitations on their daily activities.