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Main Title Assessment of Ambient UFP Health Effects: Linking Sources to Exposure and Responses in Extrapulmonary Organs.
Author G. Oberdorster ; A. Elder ; J. Finkelstein ; M. Frampton ; P. Hopke
CORP Author Rochester Univ., NY.; Clarkson Univ., Potsdam, NY.; GSF - Forschungszentrum fuer Umwelt und Gesundheit G.m.b.H., Neuherberg (Germany).; California Univ., San Diego.; LMU - Ludwig-Maximilians-Universitat, Munchen (Germany).; Environmental Protection Agency, Washington, DC.
Year Published 2011
Report Number EPA R827354
Stock Number PB2013-100299
Additional Subjects Particulates ; Health effects ; Exposure ; Respiratory system ; Age ; Air pollution ; Atherosclerotic disease ; Cardiovascular system ; Diabetes ; Diseases ; Endothelium ; Organs ; Oxidation ; Pollution sources ; Stresses ; Translocation ; Vascular system ; Ultrafine particles(UFP)
Library Call Number Additional Info Location Last
NTIS  PB2013-100299 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 35p
In summary, our studies show that ambient PM can have significant oxidative capacity, that UFP can induce significant effects not only in the respiratory tract but more importantly affect the vascular and cardiac system and that age and underlying disease (susceptibility factors) are critical modifying factors. Furthermore, our demonstration of their efficient translocation from deposition sites in the respiratory tract to other organs such as heart and CNS provides plausibility for UFP-induced oxidative stress in those organs. Such translocation could be particularly detrimental in susceptible individuals with dysfunctional vascular endothelium as the earliest manifestation of atherosclerotic vascular disease, such as seen in type 2 diabetes. This is presently being tested in ongoing studies.