||Toxicokinetic Modeling of (14)C-Pentachlorophenol in the Rainbow Trout ('Salmo gairdneri).
McKim, J. M. ;
Schmieder, P. K. ;
Erickson, R. J. ;
||Environmental Research Lab.-Duluth, MN.
Reaction kinetics ;
Water pollution effects(Animals) ;
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An in vivo trout model was used to monito the major routes and rates of pentachlorophenol uptake and elimination. A first-order kinetic model and observed data were used to generate fitted and predicted rate constants required for evaluation of first-order kinetic. The fitted first-order uptake-depuration curves for all experimental animals agreed with those observed suggesting first-order kinetics approximated the behavior of whole-body (14)C-pentachlorophenol (PCP) burden.