Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Exposure to Peroxyacetyl Nitrate on Susceptibility to Acute and Chronic Bacterial Infection.
Author Thomas, Gail B. ; Fenters, James D. ; Ehrlich, R. ; Gardner, D. E. ;
CORP Author IIT Research Inst., Chicago, IL.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Year Published 1981
Report Number EPA-68-02-1273; EPA-600/J-81-603;
Stock Number PB83-140822
Additional Subjects Air pollution ; Bacterial diseases ; Aerosols ; Nitrogen organic compounds ; Susceptibility(Physiology) ; Mice ; Laboratory animals ; Reprints ; Peroxyacetyl nitrate ; Streptococcus pyogenes ; Photochemical oxidants
Library Call Number Additional Info Location Last
NTIS  PB83-140822 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 18p
A significant increase in mortality due to acute respiratory pneumonia caused by inhalation of Streptococcus pyogenes aerosol was seen after a single 3-h exposure of mice to 14.8-28.4 mg/cu.m. peroxyacetyl nitrate (PAN). The excess mortality ranged from 8 to 39% and the decrease in survival time from 2.4 to 7.9 d. A single exposure to 25.0 mg/cu.m. PAN resulted in a significant increase in total number of cells lavaged from the lungs but somewhat decreased levels of ATP in alveolar macrophages. PAN did not produce any marked changes in a chronic respiratory infection in mice as measured by Mycobacterium tuberculosis lung titers.