Record Display for the EPA National Library Catalog


Main Title Neurophysiological Effects of 30 Day Chronic Exposure to Toluene in Rats.
Author Dyer, R. S. ; Muller, K. E. ; Janssen, R. J. ; Barton, C. N. ; Boyes, W. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/254;
Stock Number PB85-176626
Additional Subjects Toluene ; Toxicology ; Bioassay ; Neurophysiological effects ; Exposure ; Rats ; Laboratory animals ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB85-176626 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Long-Evans hooded rats were exposed to 1000 ppm toluene or 0 ppm toluene 6 hr/day, 5 days/week for 30 days. Following removal from the exposure conditions (18-26 hr) flash-evoked potentials were recorded to paired light flashes and pentylenetetrazol (PTZ) seizure properties were examined. No alterations were found in the response to the first flash, but alterations in the recoverability of the nervous system were demonstrated by significant latency shifts in the response to the second of the paired flashes, using first flash latencies as covariates. No significant alterations were found in PTZ seizures. The data indicated that at these exposure levels toluene produced a small but significant alteration in brain function, even after toluene had been completely metabolized.