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RECORD NUMBER: 34 OF 37

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Main Title

Studies on the Toxicity of O,O-Dimethyl-2,2-Dichlorovinyl Phosphate (DDVP).

Author

Durham, William F. ; Gaines, Thomas B. ; McCauley, Robert H. ; Sedlak, Vincent A. ; Mattson., Arnold M. ;

CORP Author

Communicable Disease Center, Atlanta, Ga.

Year Published

1956

Stock Number

PB-278 093

Additional Subjects

Toxicology ; Pesticides ; Insecticides ; Bioassay ; Dosage ; Chlorine organic compounds ; Rats ; Laboratory animals ; Experimental data ; Lethal dosage ; Cholinesterase ; Tables(Data) ; Exposure ; Respiratory system ; Monkeys ; Chickens ; Reprints ; Toxic substances ; DDVP insecticide ; Phosphoric acid/(dichlorovinyl-ester)-(dimethyl-ester)

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB-278 093	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

10p

Abstract

The acute oral and dermal L.D.60 values of DDVP for male white rats were found to be 80 and 107 mg/kg, respectively. The corresponding values for females were 56 and 75 mg/kg. Pure DDVP was found, under the conditions studied, to be somewhat more toxic than the technical material. Feeding for 90 days on dietary levels of DDVP up to 1000 ppm caused no signs of intoxication in rats. However, dietary levels as low as 50 ppm produced definite lowering of plasma and erythrocyte cholinesterase levels. Monkeys confined for two weeks in Peet-Grady chambers which had been sprayed with 100 and 195 mg of DDVP per square foot showed depletion of both plasma and erythrocyte cholinesterase.

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