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RECORD NUMBER: 22 OF 39

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Main Title

Hormonal Influences on DDT Metabolism in the White Rat.

Author

Durham, William F. ; Cueto, Jr., Cipriano ; Hayes, Jr., Wayland J. ;

CORP Author

Communicable Disease Center, Savannah, Ga.

Year Published

1956

Stock Number

PB-278 087

Additional Subjects

Hormones ; DDT ; Toxicology ; Pesticides ; Insecticides ; Esters ; Oxygen organic compounds ; Metabolism ; Rats ; Absorption(Biology) ; Sex ; Males ; Females ; Fats ; Testosterone ; Bioassay ; Laboratory animals ; Experimental data ; Liver ; Body weight ; Reprints ; Metabolites ; DDE insecticide ; Diethylstilbestrol ; Pesticide residues ; Toxic substances ; Propionic acid/(testosterone-ester) ; Bioaccumulation

Holdings

Library	Call Number	Additional Info	Location	Last Modified	Checkout Status
NTIS	PB-278 087	Some EPA libraries have a fiche copy filed under the call number shown.		07/26/2022

Collation

Abstract

The influence of diethylstilbestrol (DES) and testerone propionate (TP) on the storage of DDT and its metabolite, DDE, was studied in normal and in gonadectomized rats. As expected, TP dosage increased the growth of female rats while DES administration inhibited the growth of males. Both hormones inhibited gonadal growth. Rats that received either DDT or hormone showed an increased liver weight/body weight ratio as compared to control animals. This effect was more marked in males than in females. DES increased DDT and DDE storage in fat in the male while TP decreased these values in the female. Similar effects of hormone dosage were noted on the ratio of DDE to total DDT-derived material stored in fat.

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