Main Title |
Sister-Chromatid Exchange Induction in Rat Maternal, Embryonic and Extra-Embryonic Cells After in vivo Exposure to 4-Nitroquinoline 1-Oxide. |
Author |
Sharma, R. K. ;
Dunn, R. ;
Allen, J. W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. |
Year Published |
1984 |
Report Number |
EPA/600/J-84/379; |
Stock Number |
PB86-209798 |
Additional Subjects |
Toxicology ;
In vivo analysis ;
Rats ;
Reprints ;
Sister chromatid exchange ;
Genotoxicity ;
Nitroquinoline oxide
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-209798 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
Genetic damage is associated with various embryo pathologies; and many teratogens and transplacental carcinogens are known to be genotoxic. The present study was aimed at charaterizing SCE induction levels in rodent maternal, embryonic and extra-embryonic cells after maternal exposure to 4NQO. Tissue-specific assessments were made at various gestational ages, and thus stages of placental development. Embryo liver, and yolk sac - the malfunction of which has been implicated in teratogenic mechanisms were assessed with a particular view to whether they would show relatively low levels of SCE induction and thereby lend support to the concept of a protective placental barrier to 4NQO. A previously established rat system allowing for in vivo SCE induction analyses of maternal marrow and embryo liver or yolk sac was used for these studies. |