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Main Title Solubility Properties in Polymers and Biological Media. 7. An Analysis of Toxicant Properties That Influence Inhibition of Bioluminescence in 'Photobacterium phosphoreum' (The Microtox Test).
Author Kamlet, M. J. ; Doherty, R. M. ; Veith, G. D. ; Taft, R. W. ; Abraham, M. H. ;
CORP Author Environmental Research Lab.-Duluth, MN. ;Naval Surface Weapons Center White Oak Lab., Silver Spring, MD. ;California Univ., Irvine. Dept. of Chemistry. ;Surrey Univ., Guildford (England).
Year Published 1986
Report Number EPA/600/J-86/233;
Stock Number PB87-168126
Additional Subjects Toxicity ; Bioluminescence ; Fishes ; Chemical tests ; Solubility ; Chemical analysis ; Organic compounds ; Hydrogen bonds ; Contaminants ; Polymers ; Reprints ; Photobacterium phosphorem
Library Call Number Additional Info Location Last
NTIS  PB87-168126 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Inhibition of bioluminescence in Photobacterium phosphoreum (the Microtox test) has been proposed as a cost-effective prescreening procedure to eliminate the relatively more innocuous chemicals from testing programs for toxicities of organic chemicals to fish. The biological response was a function of the solvatochromic parameters that measure dipolarity/polarizability, hydrogen-bond acceptor basicity, and hydrogen-bond donor acidity of the solute (toxicant). The relationship applies to compounds that act by a nonreactive toxicity mechanism, and it is suggested that for certain compounds, which are outliers relative to the above equation, reactive toxicity properties mask the effects of the nonreactive mechanism. The above equation is compared with a correlation of log EC50 with octanol/water partition coefficients.