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OLS Field Name OLS Field Data
Main Title Subchronic Toxicity of Para-Cresol in Sprague Dawley Rats: MBA Chemical No. 25.
Author Dietz, D. ; Mulligan, L. T. ;
CORP Author Research Triangle Inst., Research Triangle Park, NC. ;Microbiological Associates, Bethesda, MD.;Environmental Protection Agency, Washington, DC. Office of Solid Waste.
Year Published 1988
Report Number EPA-68-01-7075; EPA/530/SW-88/025;
Stock Number PB88-195292
Additional Subjects Toxicology ; Dosage ; Ingestion(Biology) ; Bioassay ; Laboratory animals ; Pathology ; Mortality ; Para cresol ; CAS 106-44-5 ; 4-cresol
Library Call Number Additional Info Location Last
NTIS  PB88-195292 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1988
Collation 378p
The study examined the oral toxicity of para-cresol (p-cresol) in Sprague Dawley rats during 13 weeks of oral gavage administration. Dose levels studied were 0, 50, 175 and 600 mg/kg/day. Three females treated with the high dose of p-Cresol died during the first three days of the study. Signs of central nervous system (CNS) depression were apparent in high-dose males and females. Reductions in body weight gain were seen for males and females treated at the high dose level and to a lesser extent in the mid dose males. Para-cresol was hepatotoxic, nephrotoxic, and induced a mild anemic state. Based on the results of the present investigation, 50 mg/kg/day appears to be the level at which no toxic effects were observed under the conditions of the present study.